steam – Cannot use protontricks, winetricks, because wine is looking for libraries in wrong location

Wine seems to be looking for libraries / shared objects in the wrong location. Running winetricks or protontricks to establish compatability for a game gets me to the following error.

wine: failed to initialize: /home/vagrant/build-proton_5.13-local/dist-wine32/lib/wine/ntdll.dll.so: cannot open shared object file: No such file or directory
Game is considered exited.

Another example

/home/ubuntu/.cache/protontricks/proton/proton_5.13-local/bin/wine cmd.exe /c echo '%ProgramFiles%' returned empty string, error message "wine: failed to initialize: /home/vagrant/build-proton_5.13-local/dist-wine32/lib/wine/ntdll.dll.so: cannot open shared object file: No such file or directory" 

I’ve tried a number of troubleshooting suggestions but it’s all felt like fitting square pegs into circle shaped holes. I’ve tried uninstalling and reinstalling Proton, building it from source, fiddling with Wine versions, reinstalling winetricks and protontricks, etc. Nothing budges this error. I’m presuming that there are environmental variables that aren’t being set, but I’m not sure what they are or ought to be. This is my suspicion because I am aware that Proton is built using vagrant, and those seem to be the default directories it’s looking for here.